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Supelco

(+)-1-(9-Fluorenyl)ethyl chloroformate solution

≥18 mM in acetone, for chiral derivatization, LiChropur™

Synonym(s):

(+)-FLEC solution

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About This Item

Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
107474-79-3
Molecular Weight:
272.73
MDL number:
MFCD00043429
UNSPSC Code:
12000000
PubChem Substance ID:
329752390
NACRES:
NA.22

grade

derivatization grade ((chiral))
for chiral derivatization

Quality Level

100

product line

ChiraSelect™

optical purity

enantiomeric ratio: ≥99.0:1.0 (HPLC)

quality

LiChropur™

concentration

≥18 mM in acetone

technique(s)

HPLC: suitable

refractive index

n20/D 1.359

storage temp.

2-8°C

SMILES string

ClC(=O)OC(C1c2c(cccc2)c3c1cccc3)C

InChI

1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3

InChI key

SFRVOKMRHPQYGE-UHFFFAOYSA-N

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General description

(+)-1-(9-Fluorenyl)ethyl chloroformate [(+)-FLEC] is a chiral derivatizing reagent. It helps in separating enantiomers of α-amino acids, as well as helps in determining its optical purity using HPLC method.

Application

(+)-FLEC may be used in enantioselective analysis of glufosinate using reversed-phase high-performance liquid chromatography system coupled with a fluorescence detection system.

Physical form

solution, 5 mg in 1 mL acetone

Other Notes

Chiral derivatizing agent for primary and secondary amino acids and amines. The derivatives are separated by reversed-phase LC with fluorescence detection for determining the enantiomeric purity

Recommended products

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Legal Information

ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

1.4 °F

flash_point_c

-17 °C

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG5302
BCCB4426
BCBZ3702
BCBK1551V

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Separation of enantiomers of a-hydroxy acids by reversed-phase liquid chromatography after derivatization with 1-(9-fluorenyl) ethyl chloroformate.
Fransson, Bengt, and Ulf Ragnarsson.
Journal of Chromatography A, 827, 31-36 (1998)
E Frigerio et al.
Journal of chromatography. A, 660(1-2), 351-358 (1994-02-04)
A sensitive and selective high-performance liquid chromatographic method for the determination of reboxetine enantiomers in human plasma was developed. Although two chiral centres are present in reboxetine, its stereospecific synthesis leads to two rather than four possible enantiomers. After extraction
Y Bergqvist et al.
Journal of chromatography, 652(1), 73-81 (1994-01-14)
A sensitive, stereoselective and rapid reversed-phase liquid chromatographic method for the determination of (SR)- and (RS)-mefloquine enantiomers in 100 microliters plasma and capillary blood collected on chromatographic paper is presented. The assay involves protein precipitation from plasma, liquid-liquid extraction of
K C Chan et al.
Electrophoresis, 16(4), 504-509 (1995-04-01)
Direct enantiomeric separations of some racemic amino acids derivatized with 9-fluorenylmethyl chloroformate were obtained using cyclodextrin-modified micellar electrokinetic chromatography (CD/MEKC) with a buffer made up of 5 mM sodium borate (pH 9.2), 150 mM sodium dodecyl sulfate (SDS) and 40
J Sukbuntherng et al.
Journal of analytical toxicology, 19(3), 139-147 (1995-05-01)
To study the disposition kinetics of methamphetamine (MAP), we have developed a sensitive high-performance liquid chromatographic (HPLC) assay to quantitate the enantiomers of MAP and its major metabolites, amphetamine (AP), p-hydroxymethamphetamine (p-OH-MAP), and p-hydroxyamphetamine (p-OH-AP), the latter two of which
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