11709

Barbituric acid

for spectrophotometric det. of cyanide, ≥99.5%

• Synonym(s): 2,4,6-Trihydroxypyrimidine, Malonylurea
• Empirical Formula (Hill Notation): C₄H₄N₂O₃
• CAS Number: 67-52-7
• Molecular Weight: 128.09
• Beilstein/REAXYS Number: 120502
• EC Number: 200-658-0
• MDL number: MFCD00006666
• UNSPSC Code: 12000000
• PubChem Substance ID: 329749535
• NACRES: NA.21

Properties

• Quality Level: 100
• assay: ≥99.5% (HPLC); ≥99.5%
• form: solid
• quality: for spectrophotometric det. of cyanide
• technique(s): UV/Vis spectroscopy: suitable
• ign. residue: ≤0.05%
• mp: 248-252 °C (dec.) (lit.)
• anion traces: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤500 mg/kg
• cation traces: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; Mg: ≤10 mg/kg; Mn: ≤5 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• SMILES string: O=C1CC(=O)NC(=O)N1
• InChI: 1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)
• InChI key: HNYOPLTXPVRDBG-UHFFFAOYSA-N

Description

General description

Barbituric acid is also known as malonurea or 6-hydroxyuracil, it is an odourless powder and is soluble in water. It has a very high pharmacological activity and can be used to synthesize addition derivatives of it, to be used in novel drug discovery. It basically acts on the central nervous system (CNS) depressants, thereby possessing a wide range from mild sedation to total anaesthesia.

Application

Barbituric acid with aromatic aldehydes was used in an experimental study, meant to demonstrate the increased efficiency of Knoevenagel condensation reaction for barbituric acid and various aromatic aldehydes on basic alumina, in the absence of organic solvents under microwave irradiation. It may also be used in electrochemical oxidation of iodine, using cyclic voltammetry and controlled-potential coulometry.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 302.0 °F - closed cup
• flash_point_c: 150.00 °C - closed cup
• ppe: Eyeshields, Gloves, type N95 (US)