10171832001
Roche
Aldehyde Dehydrogenase
from yeast
Synonym(s):
Aldehyde dehydrogenase
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About This Item
Recommended Products
biological source
yeast
Quality Level
form
lyophilized
specific activity
~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)
packaging
pkg of 250 U
manufacturer/tradename
Roche
optimum pH
8.75
relevant disease(s)
cancer
storage temp.
2-8°C
General description
Aldehyde dehydrogenase (ALDH) is a soluble enzyme and its activity depends on potassium ions and cysteine. The family of ALDH comprises of 19 genes in human. ALDH gene is expressed in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. ALDH is a component of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) recycling systems.
Application
Aldehyde Dehydrogenase has been used to evaluate fiber-optic biosensors for measurement of acetaldehyde (AcH) in liquid phase (AcH biosensor).
Biochem/physiol Actions
Aldehyde dehydrogenase (ALDH) regulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene are associated with Sjogren Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH takes part in the oxidation of aldehydes to acids. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.
Quality
Contaminants: <0.01% “NADH oxidase”, ADH, and LDH each
Physical form
Enzyme is stabilized with potassium phosphate buffer, pH approximately 6.
Other Notes
For life science research only. Not for use in diagnostic procedures.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - STOT RE 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
does not flash
flash_point_c
does not flash
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Yeast Aldehyde Dehydrogenase II. PROPERTIES OF THE HOMOGENEOUS ENZYME PREPARATIONS
Charles R. Steinman and WILLIAM B. JAKOBY
The Journal of Biological Chemistry, 243(4), 730-734 (1965)
Improved sensitivity of acetaldehyde biosensor by detecting ADH reverse reaction-mediated NADH fluoro-quenching for wine evaluation
Iitani K, et al.
ACS sensors, 2(7), 940-946 (2017)
Yeast aldehyde dehydrogenase.
S BLACK
Archives of biochemistry and biophysics, 34(1), 86-97 (1951-11-01)
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
Chen CH, et al.
Science (New York, N.Y.), 321(5895), 1493-1495 (2008)
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Marchitti SA, et al.
Expert Opinion on Drug Metabolism & Toxicology, 4(6), 697-720 (2008)
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