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MAB5416

Sigma-Aldrich

Anti-Glutamate Receptor 3 Antibody, clone 3B3

clone 3B3, Chemicon®, from mouse

Synonym(s):

AMPA-selective glutamate receptor 3, Glutamate receptor ionotropic, AMPA 3, glutamate receptor 3, glutamate receptor C, glutamate receptor subunit 3, glutamate receptor, ionotrophic, AMPA 3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

3B3, monoclonal

species reactivity

monkey, mouse, human

species reactivity (predicted by homology)

rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_000840.2

UniProt accession no.

P42263

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIA3(2892)

General description

AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition.There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. Millipore’s anti-GluR2/3 antibody is useful for localizing expression of GluR2/GluR3 receptor assemblies in the PSD.

Specificity

Reacts with Glutamate Receptor 3 (GluR3). No cross reactivity with GluR2.

Immunogen

Fusion protein, N-terminus of GluR3

Application

Anti-Glutamate Receptor 3 Antibody, clone 3B3 is an antibody against Glutamate Receptor 3 for use in WB, IC, IH, IH(P).
Immunohistochemistry: A previous lot of this antibody was used in IH.

Optimal working dilutions must be determined by end user.

Quality

Western Blot Analysis: A previous lot of this antibody was used in WB.

Target description

~ 110 kDa

Physical form

Format: Purified
Liquid in PBS. Contains no preservative.

Analysis Note

Control
Brain

Hippocampal tissue

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals.
Fumino Fujiyama, Eriko Kuramoto, Keiko Okamoto, Hiroyuki Hioki, Takahiro Furuta et al.
The European Journal of Neuroscience null
Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus.
Moga, Diana E, et al.
The Journal of Comparative Neurology, 462, 15-28 (2003)
Dopamine alters AMPA receptor synaptic expression and subunit composition in dopamine neurons of the ventral tegmental area cultured with prefrontal cortex neurons.
Gao, C; Wolf, ME
The Journal of Neuroscience null
Janusz Tucholski et al.
Schizophrenia research, 146(1-3), 177-183 (2013-03-07)
Numerous studies have demonstrated brain region- and subunit-specific abnormalities in the expression of subunits of the AMPA subtype of glutamate receptors in schizophrenia. In addition, abnormalities in the expression of proteins that regulate the forward trafficking of AMPA receptors through
Evolutionarily conserved pattern of AMPA receptor subunit glycosylation in Mammalian frontal cortex.
Tucholski, J; Pinner, AL; Simmons, MS; Meador-Woodruff, JH
Testing null
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