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Key Documents

MAB3414

Sigma-Aldrich

Anti-Cytokeratin 8 Antibody, clone 4.1.18

clone 4.1.18, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4.1.18, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_002273.2

UniProt accession no.

P05787

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KRT8(3856)

Specificity

The antibody reacts with human cytokeratin 8. There is no cross reactivity with human cytokeratin No. 7, 17, 18, or 19. Anti-cytokeratin No. 8 decorates single epithelia in stomach, colon, and small intestine, gall bladder, liver (bile ducts and hepatocytes) as well as pancreatic ducts and mammary gland ducts.

Immunogen

Cytoskeletal preparation of MCF-7 cells.

Application

This Anti-Cytokeratin 8 Antibody, clone 4.1.18 is validated for use in WB, IC, IH, IH(P) for the detection of Cytokeratin 8.
Western blot Immunocytochemistry Immunohistochemistry: Frozen sections, acetone fixed (5-10 μg/mL)

Paraffin sections, after trypsin treatment (5-20 μg/mL)

Optimal-working dilutions must be determined by end user.

Linkage

Replaces: 04-588

Physical form

Format: Purified
Lyophilized from 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Patterns of expression and organization of cytokeratin intermediate filaments.
Quinlan, R A, et al.
Annals of the New York Academy of Sciences, 455, 282-306 (1985)
Cristián Vela Hinojosa et al.
PloS one, 8(9), e75062-e75062 (2013-10-03)
The mammary gland has long drawn the attention of the scientific community due to the limited knowledge of some fundamental aspects involved in the control of its function. Myotis velifer, a microchiropteran species, provides an interesting model to study some
Sinyoung Kim et al.
International journal of molecular medicine, 27(5), 701-706 (2011-02-25)
Although recent studies have demonstrated the in vitro hepatic differentiation potential of mesenchymal stem cells (MSCs), the evidence supporting the in vivo engraftment of MSCs, hepatic differentiation and improvement of hepatic function is still lacking. We investigated in vivo hepatic
Yan Zhuang et al.
Molecular carcinogenesis, 54(12), 1656-1667 (2014-10-21)
Epigenetic regulation of gene expression is critical to phenotypic maintenance and transition of human breast cancer cells. HOX antisense intergenic RNA (HOTAIR) is a long intergenic non-coding RNA that epigenetically represses gene expression via recruitment of enhancer of zeste homolog
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.
R Moll et al.
Cell, 31(1), 11-24 (1982-11-01)

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