MAB3318
Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4
clone 136-13H4, Chemicon®, from mouse
Synonym(s):
Tissue Inhibitor of Metalloproteinase-3
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
136-13H4, monoclonal
species reactivity
rabbit, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... TIMP3(7078)
Specificity
Specifically reacts with human TIMP-3. This is a purified mouse monoclonal antibody to an oligopeptide of SWYRGWAPPDKSIINATDP (residue 170-188) on human tissue inhibitor of metalloproteinases-3 (human TIMP-3).
MAB3318 cross-reacts with rabbit TIMP-3, but does not react with human TIMP-1 and human TIMP-2.
MAB3318 cross-reacts with rabbit TIMP-3, but does not react with human TIMP-1 and human TIMP-2.
Immunogen
Epitope: a.a. 170-188
Oligopeptide of SWYRGWAPPDKSIINATDP (residue 170-188) on human tissue inhibitor of metalloproteinases-3.
Application
Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4 is an antibody against TIMP-3 for use in IH(P) & WB.
Immunoblotting: 2 ug/mL
Immunohistochemistry (Paraffin):10ug/mL
Immunohistochemistry (Frozen): 2 ug/mL
Immunohistochemistry (Paraffin):10ug/mL
Immunohistochemistry (Frozen): 2 ug/mL
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
Target description
26 kDa
Physical form
Format: Purified
Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin.
Protein A purified
Storage and Stability
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analysis Note
Control
Breast carcinoma tissue
Breast carcinoma tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Manufactured by Daiichi Fine Chemical Co., Ltd
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.
Fionula M Brennan,Patricia Green,Parisa Amjadi,Heidi J Robertshaw et al.
European Journal of Immunology null
Catabolic properties of microdissected human endosteal bone lining cells.
C Dierkes,M Kreisel,A Schulz,J Steinmeyer,J-C Wolff,L Fink
Calcified Tissue International null
S S Apte et al.
Genomics, 19(1), 86-90 (1994-01-01)
The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. We have isolated overlapping cDNAs encoding a novel human TIMP, TIMP-3. The cDNAs contain
C G Wilde et al.
DNA and cell biology, 13(7), 711-718 (1994-07-01)
The tissue inhibitors of metalloproteinases (TIMPs) comprise a family of proteins, of which two members have so far been described in humans. We have cloned and sequenced a third human TIMP (hTIMP-3) from phorbol ester-differentiated THP-1 cells stimulated with bacterial
Lluis Catasus et al.
Histopathology, 62(4), 632-641 (2013-02-06)
Expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) has been found to be decreased in several types of cancer by promoter gene hypermethylation. However, little is known regarding the silencing effect of TIMP3 promoter hypermethylation on gene and protein expression in
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