GF430-M
HumanKine® IL-6, Human Recombinant Xeno-Free
Synonym(s):
IL6, Interleukin-6
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.27
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General description
HumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free.
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD.
Application
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Quality
Bioactivity assay: Determined by the dosedependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic
indicator cell line). ED50 is typically 0.2-1 ng/ml.
indicator cell line). ED50 is typically 0.2-1 ng/ml.
Physical form
Product is presented in PBS and filtered through a 0.2 micron filter before lyophilization.
Preparation Note
HumanKine IL-6 is manufactured using all non-animal reagents and is considered Xeno-Free
Storage and Stability
Store at -20°C for up to 4 months from date of receipt. Further dilutions should be made into appropriate buffer or medium to which protein has been added.
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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