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AB6030

Sigma-Aldrich

Anti-Integrin alpha 10 (ITGA10) Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Integrin, alpha 10, integrin alpha-10

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rhesus macaque, primate, human

species reactivity (predicted by homology)

canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), pig (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_003628

UniProt accession no.

O75578

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGA10(8515)

General description

Integrins are transmembrane proteins that are involved in interactions cell-to-cell and cell-to-extracellular matrix (ECM) adhesion. Integrins play diverse roles including cell migration, development, wound healing, differentiation, and apoptosis. Integrin alpha 10 subunit (ITGA10), along with integrin beta 1, is thought to be an essential part of a novel collagen type II receptor expressed mainly in chondrocytes and cartilage tissue.

Specificity

Other homologies: rat (93% sequence homology).
This antibody recognizes the extracellular domain of Integrin alpha 10.

Immunogen

Epitope: Extracellular Domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human Integrin alpha-10.

Application

Detect Integrin alpha 10 (ITGA10) using this Anti-Integrin alpha 10 (ITGA10) Antibody validated for use in WB.
Research Category
Cell Structure
Research Sub Category
Integrins

Adhesion (CAMs)

Quality

Evaluated by Western Blot in SW-1353 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin alpha10 in 10 µg of SW-1353 cell lysate.

Target description

~127 kDa observed

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
SW-1353 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yibo Song et al.
Regenerative therapy, 21, 342-350 (2022-09-27)
To probe the impacts and biological roles of miR-4739/ITGA10 on the proliferation, differentiation and apoptosis of osteoblasts. Bioinformatics analysis was conducted to screen the key genes in osteoporosis. The upstream miRNAs of ITGA10 were predicted by TargetScan. KEGG pathway enrichment
B E Engel et al.
Cell death & disease, 4, e938-e938 (2013-11-30)
pRb is known as a classic cell cycle regulator whose inactivation is an important initiator of tumorigenesis. However, more recently, it has also been linked to tumor progression. This study defines a role for pRb as a suppressor of the
Tobias G Schips et al.
Nature communications, 10(1), 76-76 (2019-01-10)
Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal stability through increased integrin and dystroglycan attachment complexes, here we

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