biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SNCG(6623)
Specificity
Gamma synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB6466 with a and b-synuclein. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.
Immunogen
Peptide corresponding to the amino acids 114-127 of human gamma synuclein protein.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
This Anti-Synuclein Antibody, γ is validated for use in WB, IH for the detection of Synuclein.
Western blot: 1:500-1:1,000.
Immunohistochemistry: 1:1,000 on frozen tissue.
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:1,000 on frozen tissue.
Optimal working dilutions must be determined by end user.
Linkage
Replaces: 04-1050
Physical form
Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Storage and Stability
Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages.
Kunikazu Tanji, Fumiaki Mori, Tadaatsu Imaizumi, Hidemi Yoshida, Tomoh Matsumiya et al.
Pathology International null
M C Quilty et al.
Experimental neurology, 182(1), 195-207 (2003-06-25)
Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons and
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