AB5403
Anti-NMDAR2B Antibody, phosphoTyr 1472
Chemicon®, from rabbit
Synonym(s):
Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
rat ... Grin2B(24410)
Specificity
NMDAR2B, phosphoTyr1472. The antibody recognizes a protein of ~180 kDa in Western blot. The labeling of the NMDAR2B protein in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. Two additional lower molecular weight bands are present in Western blots of rat brain.
Immunogen
Epitope: phosphoTyr 1472
Synthetic peptide corresponding to amino acids surrounding the phosphoTyr1472 of rat NMDAR2B.
Application
Anti-NMDAR2B Antibody, phosphoTyr 1472 is an antibody against NMDAR2B for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Western blot: 1:1,000
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Physical form
Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 μg/mL BSA, 50% glycerol and 0.09% sodium azide.
Storage and Stability
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Sofia Lopes et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(26), E3755-E3763 (2016-06-09)
Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyperphosphorylation and missorting into dendritic spines followed by memory
Hong-Bin Yang et al.
Journal of neurochemistry, 116(1), 93-104 (2010-11-09)
Selective inhibition of GluN2B-containing NMDA receptor (GluN2BR) in spinal dorsal horn effectively alleviates inflammatory pain, suggesting the up-regulation of GluN2BR function involved in central sensitization. Previous studies have demonstrated that the increase in GluN2BR synaptic expression serves as a key
Sehoon Won et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(32), E4736-E4744 (2016-07-28)
Phosphorylation regulates surface and synaptic expression of NMDA receptors (NMDARs). Both the tyrosine kinase Fyn and the tyrosine phosphatase striatal-enriched protein tyrosine phosphatase (STEP) are known to target the NMDA receptor subunit GluN2B on tyrosine 1472, which is a critical
Jérémy Ferrier et al.
PloS one, 8(10), e77828-e77828 (2013-11-10)
Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly
Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats.
Dan Ren et al.
Neuroscience bulletin, 38(4), 342-358 (2021-12-16)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a
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