AB3116
Anti-Bcl-xL Antibody, Phospho-specific
serum, Chemicon®
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... BCL2L1(598)
General description
Bcl-XL is one of the anti-apoptotic members of the Bcl-2 family of apoptosis regulators and is overexpressed in many human cancers. Studies by Dr. Haldar and his associates suggest that microtubule damaging drugs like Taxol or 2-methoxyestradiol induce phosphorylation of Bcl-XL at serine 62 by kinases such as Jun and this allows those cells to die by apoptosis.
Specificity
AB3116 is specific for the Bcl-xL phosphorylated on serine 62. It does not recognize the unphosphorylated form of the protein.
Immunogen
Epitope: Phospho-specific
Synthetic phosporylated peptide corresponding to a sequence encompassing serine 62 of human Bcl-xL conjugated to KLH.
Application
Detect Bcl-xL using this Anti-Bcl-xL Antibody, Phospho-specific validated for use in WB.
Immunoblotting: Recommended dilution is 1:100
Optimal dilutions must be determined by end-user.
Optimal dilutions must be determined by end-user.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
Tumor Markers
BCL2 & Inhibition
Tumor Markers
Physical form
Liquid rabbit serum containing no preservatives.
Storage and Stability
Maintain at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis
Basu, A. and Haldar, S.
Febs Letters, 538, 41-47 (2003)
A Notte et al.
Cell death & disease, 4, e638-e638 (2013-05-18)
Cancer cell resistance against chemotherapy is still a heavy burden to improve anticancer treatments. Autophagy activation and the development of hypoxic regions within the tumors are known to promote cancer cell resistance. Therefore, we sought to evaluate the role of
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