AB15508
Anti-Iron Regulatory Protein 2 Antibody
Chemicon®, from rabbit
Synonym(s):
IRP-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... IREB2(3658)
General description
Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5′-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset.
Specificity
Iron regulatory protein 2 (IRP-2). The immunogen sequence has no significant homology with IRP-1.
The immunogen sequence is 100% conserved in human, rat, and mouse IRP-2.
Immunogen
Synthetic peptide near the N-terminus of human/rat/mouse IRP-2.
Application
Detect Iron Regulatory Protein 2 using this Anti-Iron Regulatory Protein 2 Antibody validated for use in ELISA & WB.
Physical form
Format: Purified
Liquid in PBS with 0.1% BSA and 0.05% sodium azide.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Aging-related changes in the iron status of skeletal muscle.
DeRuisseau, KC; Park, YM; DeRuisseau, LR; Cowley, PM; Fazen, CH; Doyle, RP
Experimental Gerontology null
Gurugirijha Rathnasamy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(49), 17982-17995 (2011-12-14)
This study was aimed to examine the role of iron in causing periventricular white matter (PWM) damage following a hypoxic injury in the developing brain. Along with iron, the expression of iron regulatory proteins (IRPs) and transferrin receptor (TfR), which
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