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Key Documents

8.56053

Sigma-Aldrich

H-Gly-2-ClTrt resin

Novabiochem®

Synonym(s):

Glycine-2-Chlorotrityl Resin

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About This Item

UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

storage temp.

2-8°C

General description

Pre-loaded resin for synthesis of protected peptide acids containing a C-terminal glycine amino-acid residue by Fmoc SPPS. Cleavage of the protected peptide is effected by treatment with 1% TFA in DCM or 20% TFE in DCM

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

  • Development of peg-peptide conjugate based curcumin delivery systems: Discusses the use of H-Gly-2-ClTrt resin and Rink amide MBHA resin to synthesize side-chain-protected and deprotected peptides, highlighting challenges in synthesizing high-molecular-weight peptides using 2-chlorotrityl resin. (G Aydoğan, 2022).

Linkage

Replaces: 04-12-2800

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.30 - 0.90 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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