551476

Q-VD-OPh, Non-O-methylated

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem^®

• Synonym(s): InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
• Empirical Formula (Hill Notation): C₂₆H₂₅F₂N₃O₆
• Molecular Weight: 513.49
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
• Quality Level: 100
• assay: ≥90% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Sequence

Q-Val-Asp-CH₂-OPh

Physical form

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - closed cup - (Dimethylsulfoxide)
• flash_point_c: 87 °C - closed cup - (Dimethylsulfoxide)