401484

IKK-2 Inhibitor IV

InSolution, ≥95%

• Synonym(s): InSolution IKK-2 Inhibitor IV
• Empirical Formula (Hill Notation): C₁₂H₁₀FN₃O₂S
• Molecular Weight: 279.29
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: liquid
• potency: 18 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: clear pale yellow
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC₅₀ = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC₅₀ in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC₅₀ = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: 188.6 °F - closed cup - (Dimethylsulfoxide)
• flash_point_c: 87 °C - closed cup - (Dimethylsulfoxide)