36-012
Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14
clone nSyn14, Upstate®, from mouse
Synonym(s):
Anti-NACP, Anti-PARK4, Anti-PD1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
ascites fluid
antibody product type
primary antibodies
clone
nSyn14, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
shipped in
dry ice
target post-translational modification
nitration (Tyr39)
Gene Information
human ... SNCA(6622)
Specificity
α- or β-synuclein nitrated at Tyr39
Immunogen
full-length recombinant human α-Synuclein nitrated in vitro
Application
Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14 detects level of nitro-α/β-Synuclein (Tyr39) & has been published & validated for use in WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Quality
routinely evaluated by immunoblot on recombinant protein nitrated in vitro
Target description
α-Synuclein, Mr 14.5kDa
β-Synuclein, Mr 17kDa
β-Synuclein, Mr 17kDa
Physical form
Ascites
Format: Purified
ascites with 0.05% sodium azide
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Duda, J. E., et al
Annals of Neurology, 52, 205-210 (2002)
Hugo Vicente Miranda et al.
Scientific reports, 7(1), 13713-13713 (2017-10-24)
Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for
Emilio Fernández et al.
Antioxidants & redox signaling, 21(15), 2143-2148 (2014-08-16)
The research group has detected nitrosative stress and a singular version of nitrosylated serum α-synuclein in serum of Parkinson's disease (PD) patients. Dysfunction of the thyroid gland has been proposed to be linked to this disease. The aim of the
J M Souza et al.
The Journal of biological chemistry, 275(24), 18344-18349 (2000-04-05)
Intracellular proteinaceous aggregates are hallmarks of many common neurodegenerative disorders, and recent studies have shown that alpha-synuclein is a major component of several pathological intracellular inclusions, including Lewy bodies in Parkinson's disease (PD) and glial cell inclusions in multiple system
B I Giasson et al.
Science (New York, N.Y.), 290(5493), 985-989 (2000-11-04)
Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of these disorders. Using antibodies to specific nitrated tyrosine residues in alpha-synuclein, we demonstrate extensive and widespread
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