345744
Ganglioside GT1b, Trisialo, Triammonium Salt, Bovine Brain
Inhibits Con A-stimulated mitogenesis in murine T cells.
Synonym(s):
Ganglioside GT1b, Trisialo, Triammonium Salt, Bovine Brain, Neu5Acα2,3Galβ1,3GalNAcβ1,4(Neu5Acα2,8Neu5Acα2,3)Galβ1,4Glcβ1,1 Ceramide, 3NH₄
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About This Item
Empirical Formula (Hill Notation):
C95H162N5O47 · 3NH4
Molecular Weight:
2180.42
UNSPSC Code:
12352211
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (TLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
ethanol: soluble
methanol: soluble
shipped in
ambient
storage temp.
−20°C
General description
Inhibits Con A-stimulated mitogenesis in murine T cells. Lymphocyte marker in cancer patients. Readily converted to GD1b-disialoganglioside by bacterial and other mammalian neuraminidases without detergent or bile salts.
M.W. 2180.5 (based on stearoyl - 18:0).
Trisialoganglioside prepared from bovine gray matter. Readily converted to GD1b-disialoganglioside by bacterial and mammalian sialidases without detergent or bile salts. Inhibits mitogenesis in concanavalin A-stimulated murine T-cells. Lymphocyte marker in cancer patients.
Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibits Con A-stimulated mitogenesis in murine T cells
Inhibits Con A-stimulated mitogenesis in murine T cells
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Irritant (B)
Preparation Note
For use in aqueous systems, dissolve in a small amount of ethanol and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions can be filter sterilized.
Reconstitution
Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
Other Notes
Hakomori, S. 1985. Cancer Res.45, 2405.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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