300270

PARP Inhibitor III, DPQ

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
• Empirical Formula (Hill Notation): C₁₈H₂₆N₂O₂
• CAS Number: 129075-73-6
• Molecular Weight: 302.41
• MDL number: MFCD01866274
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥90% (HPLC)
• form: solid
• potency: 40 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
• InChI key: RVOUDNBEIXGHJY-UHFFFAOYSA-N

Description

General description

A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Other Notes

Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3