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218746

Sigma-Aldrich

Caspase-1 Inhibitor VI

≥95% (HPLC), powder, Caspase-1 inhibitor, Calbiochem®

Synonym(s):

Caspase-1 Inhibitor VI, Z-YVAD-FMK

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About This Item

Empirical Formula (Hill Notation):
C31H39FN4O9
Molecular Weight:
630.66
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Caspase-1 Inhibitor VI, Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5.

Quality Level

100

assay

≥95% (HPLC)
≥95% (TLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent, cell-permeable and irreversible inhibitor of caspase-1 (ICE).
A potent, cell-permeable, and irreversible inhibitor of caspase-1 (ICE), caspase-4, and caspase-5.

Biochem/physiol Actions

Cell permeable: yes
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Tyr-Val-Ala-Asp(OMe)-CH₂F*

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Eldadah, B.A., et al. 1997. J. Neurosci. 17, 6105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of dectin-1 on myeloid cells prevents

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