218744
Caspase-2 Inhibitor I
The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Caspase-2 Inhibitor I, Z-VD(OMe)VAD(OMe)-FMK
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About This Item
Empirical Formula (Hill Notation):
C32H46FN5O11
Molecular Weight:
695.73
UNSPSC Code:
12352200
NACRES:
NA.54
Recommended Products
Quality Level
assay
≥95% (HPLC)
≥95% (TLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable and irreversible inhibitor of caspase-2 (ICH-1)
An irreversible inhibitor of caspase-2 (ICH-1).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-2
caspase-2
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH₂F*
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Zahara L Chaudhry et al.
Brain sciences, 12(4) (2022-04-22)
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in host, which may exacerbate symptoms and/or
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