14-902-M
AMPK (α2, β1, γ1) Protein, active, 10 µg
Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.
About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
product line
Upstate®
specific activity
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
mol wt
Mw 30 kDa (AMPKß1)
Mw 38 kDa (AMPKγ1)
Mw 63 kDa (AMPKα2)
purified by
(Ni2+/NTA-agarose)
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
accession no.
(Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. )
NM_006252
UniProt accession no.
relevant disease(s)
diabetes; obesity; metabolic disorders
Gene Information
human ... PRKAA2(5563) , PRKAB1(5563)
General description
Application
Metabolism
Apoptosis & Cancer
Diabetes
Obesity
Metabolic Disorders
Biochem/physiol Actions
Packaging
Quality
Target description
Physical form
Storage and Stability
Other Notes
Legal Information
Disclaimer
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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