110175-M

Acetyl-Pepstatin

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (K_i = 20 nM at pH 4.7) and HIV-2 proteinase (K_i = 5 nM at pH 4.7).

• Synonym(s): Acetyl-Pepstatin, Ac-Val-Val-(3S,4S)-Sta-Ala-(3S,4S)-Sta-OH
• Empirical Formula (Hill Notation): C₃₁H₅₇N₅O₉
• CAS Number: 28575-34-0
• Molecular Weight: 643.81
• UNSPSC Code: 12352202

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: 50% acetic acid: 5 mg/mL
• storage temp.: −20°C
• InChI: 1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1
• InChI key: WKYBEGDEGRCZNF-LBTYKNIQSA-N

Description

General description

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (K_i = 20 nM at pH 4.7) and HIV-2 proteinase (K_i = 5 nM at pH 4.7).

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (K_i = 20 nM at pH 4.7) and HIV-2 proteinase (K_i = 5 nM at pH 4.7). Acts as a substrate-analog inhibitor.

Biochem/physiol Actions

Primary Target
HIV-1 proteinase

Target K_i: 20 nM at pH 4.7 against HIV-1 proteinase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ulrich, B., et al. 2000. Protein Sci.9, 2232.
Song, K., et al. 1992. Kidney Int.42, 639.
Richards, A.D., et al. 1989. FEBS Lett. 247, 113.
Richards, A.D., et al. 1989. FEBS Lett. 253, 214.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable