1.06235

Sodium acetate trihydrate

EMPROVE^® API Ph Eur,BP,JP,USP,FCC,E 262

• Synonym(s): Acetic acid sodium salt trihydrate
• Linear Formula: CH₃COONa · 3H₂O
• CAS Number: 6131-90-4
• Molecular Weight: 136.08
• Beilstein/REAXYS Number: 3732037
• MDL number: MFCD00071557
• UNSPSC Code: 12352302
• E Number: E262
• EC Index Number: 204-823-8

Properties

• agency: BP; JP; Ph. Eur.; USP
• Quality Level: 600
• reg. compliance: FCC
• product line: EMPROVE^® API
• form: solid
• autoignition temp.: 1112 °F; 607 °C
• potency: 3530 mg/kg LD₅₀, oral (Rat); >10000 mg/kg LD₅₀, skin (Rabbit)
• pH: 7.5-9.2 (20 °C, 50 g/L in H₂O)
• mp: 58 °C
• transition temp: flash point >250 °C (anhydrous substance)
• density: 1.42 g/cm³ at 20 °C
• bulk density: 900 kg/m³
• application(s): liquid formulation; parenterals; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 2-25°C
• SMILES string: O.O.O.[Na+].CC([O-])=O
• InChI: 1S/C2H4O2.Na.3H2O/c1-2(3)4;;;;/h1H3,(H,3,4);;3*1H2/q;+1;;;/p-1
• InChI key: AYRVGWHSXIMRAB-UHFFFAOYSA-M

Description

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium acetate trihydrate is used in the dialysis, insulin and infution solutions. Sodium acetate trihydrate Emprove^® API is manufactured according to ICH Q7 guidelines. A CEP and US-DMF are avaiable.

Other Notes

Enzyme substrate for acetate kinase (EC 2.7.2.1)

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable