1.03893

Benzenesulfonic acid

EMPROVE^® EXPERT

• Synonym(s): Benzene sulphonic acid, Benzenesulphonic acid, Besylic acid, Phenylsulfonic acid, Phenylsulphonic acid
• Linear Formula: C₆H₅SO₃H
• CAS Number: 98-11-3
• Molecular Weight: 158.18
• Beilstein/REAXYS Number: 742513
• EC Number: 202-638-7
• MDL number: MFCD00011689
• UNSPSC Code: 12352005

Properties

• biological source: synthetic
• Quality Level: 500
• product line: EMPROVE^® EXPERT
• form: crystalline
• technique(s): API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• impurities: endotoxins, low
• application(s): liquid formulation; parenterals; pharmaceutical
• SMILES string: OS(=O)(=O)c1ccccc1
• InChI: 1S/C6H6O3S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H,7,8,9)
• InChI key: SRSXLGNVWSONIS-UHFFFAOYSA-N

Description

General description

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Benzenesulfonic Acid Emprove^® Expert is part of this new proprietary technology platform.

Packaging

1038930500 / 500g / Glass bottle
1038931000 / 1kg / Glass bottle

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H314
• pcodes: P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 1