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Key Documents

05-883

Sigma-Aldrich

Anti-tPA (Tissue Plasminogen Activator) Antibody, clone GMA-043

clone GMA-043, Upstate®, from mouse

Synonym(s):

Anti-BAT-PA, Anti-DSPA-5

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

GMA-043, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000930

UniProt accession no.

P00750

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PLAT(5327)
mouse ... Plat(18791)

Specificity

tPA

Immunogen

Purified human tissue plasminogen activator (tPA)

Application

Detect tPA (Tissue Plasminogen Activator) using this Anti-tPA (Tissue Plasminogen Activator) Antibody, clone GMA-043 validated for use in ELISA & WB.
Research Category
Metabolism
Research Sub Category
Enzymes & Biochemistry

Quality

routinely evaluated by immunoblot on human tPA

Target description

Mr 63kDa

Physical form

100 µg of protein G purified mouse IgG1 lyophilized from 10 mM NaH2PO4, 0.15 M NaCl, 1.0% mannitol, pH 7.4.
Format: Purified
Protein G Purified

Storage and Stability

stable 2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tissue-type plasminogen activator: characteristics, applications and production technology.
Rouf, S A, et al.
Biotechnology Advances, 14, 239-266 (1996)
Stella E Tsirka
Biochemical Society transactions, 30(2), 222-225 (2002-05-25)
The tissue plasminogen activator (tPA)/plasmin proteolytic system has been implicated in both physiological and pathological processes in the mammalian brain. The physiological roles include facilitating neurite outgrowth and pathfinding. The pathological role involves mediating a critical step in the progression
Liudi Yao et al.
Cell death and differentiation, 26(5), 943-957 (2018-07-28)
The contribution of epithelial-mesenchymal transition (EMT) to human lung fibrogenesis is controversial. Here we provide evidence that ZEB1-mediated EMT in human alveolar epithelial type II (ATII) cells contributes to the development of lung fibrosis by paracrine signalling to underlying fibroblasts.

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