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M-077

Supelco

1-Mononitroglycerin solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C3H7NO5
CAS Number:
624-43-1
Molecular Weight:
137.09
EC Number:
200-835-2
MDL number:
MFCD00661062
UNSPSC Code:
41116107
PubChem Substance ID:
329817829
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

O[C@H](CO)CO[N+]([O-])=O

InChI

1S/C3H7NO5/c5-1-3(6)2-9-4(7)8/h3,5-6H,1-2H2

InChI key

HXWLJBVVXXBZCM-UHFFFAOYSA-N

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General description

1-Mononitroglycerin is a major plasma metabolite of the pharmaceutical vasodilator nitroglycerin. This Certified Spiking Solution® is suitable for use in chromatography or mass spectrometry-based applications in pharmaceutical research or clinical toxicology. Nitroglycerin is used to treat heart conditions such as angina and chronic heart failure.

Application


  • Growth of Arthrobacter sp. strain JBH1 on Nitroglycerin: This study highlights the novel capability of Arthrobacter sp. strain JBH1 to metabolize nitroglycerin as its sole source of carbon and nitrogen. The findings are critical for biotechnological applications aiming to biodegrade nitroglycerin residues in contaminated environments, presenting an effective bioremediation strategy for pollutants derived from pharmaceutical manufacturing processes (Husserl et al., 2010).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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D-002

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D-003

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D-010

1,2-Dinitroglycerin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

D-011

1,3-Dinitroglycerin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

M-001

1-Mononitroglycerin solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

M-078

2-Mononitroglycerin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

T-002

Trinitroglycerin solution, 1000 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

T-021

Trinitroglycerin solution, 1 % (w/w) in propylene glycol, ampule of 1 mL, certified reference material, Cerilliant®

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Leitold et al.
Arzneimittel-Forschung, 36(5), 814-821 (1986-05-01)
The present studies yield that all 4 metabolites of glyceryl trinitrate (Nitro Mack, GTN) cause the same typical pharmacological effects as the parent substance. Continuous infusion of 4 mg/kg/min of glyceryl 1-nitrate (G-1-N) in the conscious dog results in a
T Zimmermann et al.
Arzneimittel-Forschung, 44(4), 474-477 (1994-04-01)
The enantiomers of glyceryl-1-nitrate, a metabolite of glyceryl trinitrate, were pharmacologically characterized in vitro and in animals. In the Langendorff heart (l) G-1-N was double as potent as (d) G-1-N with respect to the enhancement of coronary flow. The two
M J Ingram et al.
The Journal of pharmacy and pharmacology, 53(3), 345-350 (2001-04-09)
Nitroxylated derivatives of non-steroidal anti-inflammatory drugs appear to offer protection against the gastrotoxicity normally associated with non-steroidal anti-inflammatory drugs, ostensibly via local production of nitric oxide. A diester of ibuprofen and glycerol-1-mononitrate has been prepared via the condensation of ibuprofen
C Romanin et al.
Journal of molecular and cellular cardiology, 20(5), 389-396 (1988-05-01)
Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence of thiols. The corresponding nitrous acid would decay leading to nitric oxide, which
H Laufen et al.
British journal of clinical pharmacology, 23(3), 287-293 (1987-03-01)
The plasma kinetics and urinary excretion of glyceryl-1-nitrate (G-1-N), a metabolite of glyceryl trinitrate with antianginal potential, were investigated in 10 healthy male volunteers, after intravenous infusion and oral administration of 20 mg G-1-N. The apparent volume of G-1-N distribution
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