D-049
N-Desmethylclobazam solution
100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C15H11ClN2O2
CAS Number:
Molecular Weight:
286.71
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
100 μg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
O=C(C1)N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O
InChI
1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
InChI key
RRTVVRIFVKKTJK-UHFFFAOYSA-N
General description
A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.
Application
- Impact on bioavailability in epilepsy treatment: A study discussed the implications of N-Desmethylclobazam on drug to drug interactions and neuropsychological impact when used as add-on therapy in drug-resistant epilepsies, highlighting its role in enhancing therapeutic bioavailability (Pietrafusa et al., 2023).
- Research on pharmacokinetic variability: Research explored the pharmacokinetic variability of N-Desmethylclobazam, emphasizing its influence by age, drug interactions, and biochemical markers of toxicity in patients with epilepsy, contributing to a deeper understanding of its pharmacological properties (Heger et al., 2024).
- Evaluation of drug-drug interactions: A comprehensive analysis investigated potential drug-drug interactions between N-Desmethylclobazam and anti-seizure medications, providing insights into its safe and effective use in clinical settings (Gaston et al., 2023).
- Synergistic effects in epilepsy management: A multicenter study on the cenobamate-clobazam interaction revealed both pharmacokinetic interactions and evidence of synergy, underscoring N-Desmethylclobazam′s potential to enhance treatment outcomes in epilepsy (Osborn and Abou-Khalil, 2023).
- Analysis of metabolites in forensic science: Research on the measurement of benzodiazepine receptor agonists′ metabolites, including N-Desmethylclobazam, outlined its detection and concentration levels in urine, offering applications in forensic toxicology (Volkova et al., 2023).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Pricing
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
35.6 °F - closed cup
flash_point_c
2 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A Guberman et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 17(3), 311-316 (1990-08-01)
Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types. A greater than 75% reduction in seizure frequency was observed in 42% (18) of the patients and
Micro-determination of clobazam and N-desmethylclobazam in plasma or serum by electron-capture gas chromatography.
N R Badcock et al.
Journal of chromatography, 421(1), 147-154 (1987-10-09)
W Löscher et al.
European journal of pharmacology, 180(2-3), 255-271 (1990-05-16)
The effects of acute and chronic treatment with the 1,5-benzodiazepine, clobazam, were studied on fully kindled amygdaloid seizures in rats. After acute dosing, clobazam significantly reduced all parameters of kindled seizures (seizure severity, seizure duration, duration of amygdalar afterdischarges) at
J M Streete et al.
Therapeutic drug monitoring, 13(4), 339-344 (1991-07-01)
The analysis of clobazam and its metabolite desmethylclobazam by high-performance liquid chromatography is described. After adding an internal standard 500 microliters of plasma is extracted under basic conditions into dichloroethane. The organic solvent is then evaporated to dryness and the
A H Bardy et al.
Brain & development, 13(3), 174-179 (1991-05-01)
Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of
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