Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

C-118

Supelco

Clomipramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H24Cl2N2
CAS Number:
17321-77-6
Molecular Weight:
351.31
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

General description

Clomipramine is a tricyclic antidepressant used to many conditions from major depression and panic disorder to narcolepsy and obsessive compulsion disorder (OCD). This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.

Application

  • Clomipramine hydrochloride solution for in vitro depression models: Research has utilized Clomipramine hydrochloride solution to develop and validate in vitro models of depression, highlighting its role as a serotonin uptake inhibitor. This aids in the pharmacokinetic profiling of antidepressants and enhances understanding of their mechanisms (Menshutina et al., 2022).
  • Application in neurotransmitter research: Clomipramine hydrochloride solution has been investigated as a tricyclic antidepressant in studies of neurotransmitter systems, particularly for its high purity and effectiveness in serotonin reuptake inhibition, essential for neurotransmitter research (Teixeira Tarley et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Xiaoyan Wang et al.
Journal of proteome research, 11(12), 6223-6230 (2012-11-01)
The protective effects of St John's Wort extract (SJ), ginsenosides (GS), and clomipramine (CPM) on chronic unpredictable mild stress (CUMS)-induced depression in rats were investigated by using a combination of behavioral assessments and metabonomics. Metabonomic analyses were performed using gas
Saied Saeed Hosseiny Davarani et al.
Analytica chimica acta, 725, 51-56 (2012-04-17)
Recent advances in electromembrane extraction (EME) methodology calls for effective and accessible detection methods. Using imipramine and clomipramine as model therapeutics, this proof-of-principle work combines EME with gas chromatography analysis employing a flame ionization detector (FID). The drugs were extracted
S A Savelyev et al.
Neuroscience, 212, 149-158 (2012-04-21)
Neonatal treatment of rat pups with clomipramine (CLI) has been shown to cause long-lasting and persistent depression-related behaviors and changes in sleep architecture and in brain-derived neurotrophic factor (BDNF) signaling in adult animals, producing an animal model of depression. However
M Komorowski et al.
Neuroscience, 223, 152-162 (2012-08-09)
Despair-related withdrawal behaviors are common symptoms of major depression (MD) and can be ascribed to a loss or absence of former rewarding events. Extinction of negatively reinforced escape behavior in the Morris Water Maze has been shown to induce despair-like
Nicola Luigi Bragazzi et al.
Critical reviews in eukaryotic gene expression, 22(3), 197-203 (2012-11-13)
Langmuir-Blodgett (LB) technology was used to build a high-sensitivity enzyme-based biosensor for medical purposes. Recombinant fungal laccase from Rigidoporous lignosus, as previously described, was used to catalyze a widely used antidepressant in a micromolar range, namely, clomipramine. The topological properties
View All Related Papers

Articles

HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide

-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder; Norclomipramine hydrochloride, ~99% (TLC), powder; Imipramine hydrochloride solution, drug standard, 1.0 mg/mL in methanol; Amitriptyline hydrochloride, ≥98% (TLC), powder; Clomipramine hydrochloride, ≥98% (HPLC), powder

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service