LM2144

Sphingosine-1-Phosphate (d17:1)

Avanti Research^™ - A Croda Brand

• Synonym(s): heptadeca-sphing-4-enine-1-phosphate
• Empirical Formula (Hill Notation): C₁₇H₃₆NO₅P
• CAS Number: 474923-27-8
• Molecular Weight: 365.45
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: ethanol solution
• packaging: pkg of 1 × 1 mL (LM2144-1EA)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• concentration: ~10 μg/mL (Refer to C of A for lot specific concentration.)
• application(s): lipidomics; metabolomics
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@]([NH3+])([H])COP([O-])(O)=O
• InChI: 1S/C17H36NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(19)16(18)15-23-24(20,21)22/h13-14,16-17,19H,2-12,15,18H2,1H3,(H2,20,21,22)/b14-13+/t16-,17+/m0/s1
• InChI key: VITGNIYTXHNNNE-LHMZYYNSSA-N

Description

General description

Sphingosine-1-phosphate (S1P) is a sphingolipid found in yeast, plants and mammals and is produced in endothelial cells. It is a cellular metabolite and signalling lipid in mammalian cells. S1P is synthesized by sphingosine kinases from sphingosine. It is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1-5).

Biochem/physiol Actions

Sphingosine 1-phosphate (S1P) plays a vital role as a secondary messenger in physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes. S1P regulates skin dendritic cells and keratinocytes

Packaging

2 mL Amber Glass Sealed Ampule (LM2144-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 55.4 °F - closed cup
• flash_point_c: 13.0 °C - closed cup