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890850O

Avanti

18:1 DAP

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

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About This Item

Empirical Formula (Hill Notation):
C41H77NO4
CAS Number:
127512-29-2
Molecular Weight:
648.05
MDL number:
MFCD01321074
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 2 × 100 mg (890850O-200mg)
pkg of 1 × 25 mg (890850O-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(CN(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

InChI

1S/C41H77NO4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(43)45-38-39(37-42(3)4)46-41(44)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,39H,5-18,23-38H2,1-4H3/b21-19-,22-20-

InChI key

NYDLOCKCVISJKK-WRBBJXAJSA-N

General description

18:1 DAP is a cationic lipid, used for the preparation of cationic liposomes.

Application

18:1 DAP is suitable for:
  • as a component of lipid bilayers
  • in the formulation of stable nucleic acid lipid vesicles
  • in the preparation and physicochemical characterization of antisense oligodeoxyribonucleotide (ODN)-containing folate (FA)-targeted or non-targeted liposomes

Packaging

5 mL Clear Glass Sealed Ampule (890850O-200mg)
5 mL Clear Glass Sealed Ampule (890850O-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

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Preparation and in-vitro evaluation of an antisense-containing cationic liposome against non-small cell lung cancer: a comparative preparation study
Saffari M, et al.
Iranian Journal of Pharmaceutical Research : IJPR, 12(Suppl), 3-3 (2013)
Transferrin-conjugated SNALPs encapsulating 2?-O-methylated miR-34a for the treatment of multiple myeloma
Scognamiglio I, et al.
BioMed Research International, 2014 (2014)
Nonequilibrium adhesion patterns at lipid bilayer junctions
Parthasarathy R, et al.
The Journal of Physical Chemistry B, 108(2), 649-657 (2004)
Qiang Cheng et al.
Nature nanotechnology, 15(4), 313-320 (2020-04-07)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that selectively target specific tissues. Here, we report a strategy

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