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880160P

Avanti

16:0 PEG2000 PE

Avanti Research™ - A Croda Brand 880160P, powder

Synonym(s):

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
474922-84-4
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 g (880160P-1g)
pkg of 1 × 200 mg (880160P-200mg)
pkg of 1 × 25 mg (880160P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880160P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[NH4+]

General description

16:0 PEG2000 PE, also known as 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DPPEmPEG2000), is a polyethylene glycol (mPEG) phospholipid conjugate. Incorporation of PEG-modified lipid conjugates in liposomes facilitates the formation of sterically stabilized liposomes (SSL), which have low reticuloendothelial system (RES) uptake and prolonged circulation lifetimes. These properties aid the PEGylated liposomes to spontaneously deliver drugs to targeted cells.

Application

16:0 PEG2000 PE, or 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] has been used in liposome preparation. It has also been used in preparation of tripeptide arginine-glycine-aspartic acid magnetoliposomes (RGD-MLPs) and poly(ethylene glycol) (PEG)- MLPs.

Packaging

20 mL Clear Glass Screw Cap Vial (880160P-1g)
5 mL Amber Glass Screw Cap Vial (880160P-200mg)
5 mL Amber Glass Screw Cap Vial (880160P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Description
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Storage Class

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kihyeun Kim et al.
Biosensors & bioelectronics, 150, 111885-111885 (2019-11-25)
Solid-phase, single-step biosensors are crucial for the development of portable, reusable, and convenient biosensors, otherwise known as point-of-care (POC) testing. Although high-performance single-step biosensors based on the principle of Förster resonance energy transfer (FRET) and using upconversion nanoparticles (UCNPs) functionalized
D Kirpotin et al.
FEBS letters, 388(2-3), 115-118 (1996-06-17)
Plasma-stable liposomes (100 nm) were prepared from dioleoylphosphatidylethanolamine (DOPE) and 3-6 mol% of a new disulfide-linked poly(ethylene glycol)-phospholipid conjugate (mPEG-DTP-DSPE). In contrast to similar preparations containing non-cleavable PEG-phospholipid conjugate, thiolytic cleavage of the grafted polymer chains facilitated rapid and complete
Ilaria Arduino et al.
International journal of pharmaceutics, 583, 119351-119351 (2020-04-28)
Here, polyethylene glycol (PEG)-stabilized solid lipid nanoparticles (SLNs) containing Pt(IV) prodrugs derived from kiteplatin were designed and proposed as novel nanoformulations potentially useful for the treatment of glioblastoma multiforme. Four different Pt(IV) prodrugs were synthesized, starting from kiteplatin by the
Maria Angela Castriciano et al.
Nanomaterials (Basel, Switzerland), 10(2) (2020-01-25)
Clusters of superparamagnetic iron oxide nanoparticles (SPIONs) have been incorporated into the hydrophobic core of polyethylene glycol (PEG)-modified phospholipid micelles. Two different PEG-phospholipids have been selected to guarantee water solubility and provide an external corona, bearing neutral (SPIONs@PEG-micelles) or positively
Carlos J Brambila et al.
Langmuir : the ACS journal of surfaces and colloids, 36(11), 2954-2965 (2020-02-25)
Phase-change perfluorocarbon microdroplets were introduced over 2 decades ago to occlude downstream vessels in vivo. Interest in perfluorocarbon nanodroplets has recently increased to enable extravascular targeting, to rescue the weak ultrasound signal of perfluorocarbon droplets by converting them to microbubbles
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