840861C

18:0-18:1 PA

1-stearoyl-2-oleoyl-sn-glycero-3-phosphate (sodium salt), chloroform

• Synonym(s): 1-octadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); SOPA; PA(18:0/18:1(9Z))
• Empirical Formula (Hill Notation): C₃₉H₇₄O₈PNa
• CAS Number: 384833-24-3
• Molecular Weight: 724.96
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 2.5 mL (840861C-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 840861C
• concentration: 10 mg/mL (840861C-25mg)
• lipid type: phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C39H75O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h18,20,37H,3-17,19,21-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/b20-18-;/t37-;/m1./s1
• InChI key: QTWIAVIWKTYOHY-HTNAYUJGSA-M

Description

General description

18:0-18:1 PA (1-stearoyl-2-oleoyl-sn-glycero-3-phosphate) is an unsaturated phosphatidic acid (PA) derivative. PA is present in the biomembranes. It is the simplest glycerophospholipid.

Application

18:0-18:1 PA (1-stearoyl-2-oleoyl-sn-glycero-3-phosphate (sodium salt)) may be used:

• as a phosphatidic acid (PA) standard to identify the corresponding radiolabeled PA on the thin-layer chromatography (TLC)
• in vesicles for experimental validation in order to identify novel phospholipids capable of inhibiting cellular membrane transportation by (ATP)-binding cassette P-glycoprotein (P-gp)
• to treat young adult mouse colonic (YAMC) cells prior to nanoclustering- forster resonance energy transfer (FRET) analysis(6)

Biochem/physiol Actions

Phosphatidic acid (PA) is the precursor for other phospholipids and acts as a signaling molecule.

Packaging

5 mL Clear Glass Sealed Ampule (840861C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• pcodes: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• target_organs: Central nervous system, Liver,Kidney
• wgk_germany: WGK 3