810215P

C12-NBD Phytosphingosine

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-phytosphingosine, powder

• Synonym(s): N-(NBD-Aminolauroyl)phytosphingosine
• Empirical Formula (Hill Notation): C₃₆H₆₃N₅O₇
• CAS Number: 388566-94-7
• Molecular Weight: 677.91
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 50 μg (810215P-50ug)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 810215P
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
• InChI key: AERBNCYCJBRYDG-KSZLIROESA-N

Description

General description

C12-NBD Phytosphingosine is a fluorescent derivative of the naturally occurring lipid compound, phytosphingosine which is localised in skin, kidney and intestines.

Phytosphingosine is a ceramide molecule localized to the stratum corneum.

Application

C12-NBD Phytosphingosine has been used as a substrate in ceramidase activity assay to study enzyme activity.

C12-NBD phytosphingosine has been used as a substrate to assay ceramidase activity.

Biochem/physiol Actions

In vitro studies using human epidermis model shows that melanin production is prevented by phytosphingosine. Hence, it is widely used in cosmetics.

Phytosphingosine (PHS) is a sphingoid lipid molecule which is known to exhibit antimicrobial and anti-inflammatory action. PHS can has the ability to increase the production of keratinocyte differentiation marker proteins, such as transglutaminase 1 and involucrin, that are responsible for the development of cornifed envelope. PHS metabolism results in the formation of glycerophospholipids, sphingolipids and even-numbered fatty acids which mainly include palmitic acid.

Packaging

5 mL Amber Glass Screw Cap Vial (810215P-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids