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790625P

Avanti

DC-Chol/DOPE Blend

Avanti Research™ - A Croda Brand 790625P, powder

Synonym(s):

DC-Chol/DOPE Blend, DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w)

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 25 mg (790625P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 790625P

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

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General description

DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (DOPE) lipid complex comprises the cationic lipid DC-Cholesterol and the neutral helper lipid DOPE.

Application

DC-Chol/DOPE Blend has been used:
  • in the preparation of liposomes for ferritin heavy chain 1 (FTH1) siRNA (small interference RNA) transfection studies
  • to compare its cytotoxicity tests with ginger derived nanoparticles in colon-26 cells
  • as a standard control in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to evaluate biocompatibility of ginger derived lipid vesicles

Biochem/physiol Actions

DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w) helps in transfection of therapeutic small interference RNA (siRNA). DC-Chol/DOPE liposomes are cationic, unilamellar and spherical in nature. It aids in improved condensation of DNA for transfection studies.

Packaging

5 mL Clear Glass Sealed Ampule (790625P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Meike-Kristin Abraham et al.
Nanotheranostics, 1(2), 154-165 (2017-10-27)
Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective:
Alberto Rodríguez-Pulido et al.
The journal of physical chemistry. B, 112(39), 12555-12565 (2008-08-30)
A 1:1 mixture of the cationic lipid 3beta-[ N-( N', N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl- sn-glycero-3-phosphoetanolamine (DOPE), has been used to compact calf-thymus DNA (CT-DNA) in aqueous buffered solution at 298.15 K. The formation process of this

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