700070P

trihydroxycholestanoic acid

Avanti Research^™ - A Croda Brand

• Synonym(s): 3α,7α,12α-trihydroxycholestanoic acid
• Empirical Formula (Hill Notation): C₂₇H₄₆O₅
• CAS Number: 547-98-8
• Molecular Weight: 450.65
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (700070P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: bile acids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1
• InChI key: CNWPIIOQKZNXBB-VCVMUKOKSA-N

Description

General description

Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.

Application

Trihydroxycholestanoic acid has been used as a sterol to test its reactivity with human mincle protein.

Biochem/physiol Actions

Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

Packaging

5 mL Amber Glass Screw Cap Vial (700070P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: No data available
• flash_point_c: No data available