QBD10761

t-Boc-N-amido-dPEG^®₁₂-acid

>95% (HPLC)

• Synonym(s): t-Boc-N-amido-PEG₁₂-COOH, t-Boc-N-amido-PEG₁₂-acid, t-Boc-PEG-acid, BocNH-​PEG₁₂-​CH₂CH₂COOH
• Empirical Formula (Hill Notation): C₃₂H₆₃NO₆₁
• Molecular Weight: 1437.81
• MDL number: MFCD13185149
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• assay: >95% (HPLC)
• form: solid or viscous liquid
• reaction suitability: reaction type: Pegylations
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C

Description

Features and Benefits

t-Boc-N-amido-dPEG₁₂-acid is a monodisperse PEG product that is useful for peptide synthesis. The 40-atoms-long dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEG_n-acid (n=4, 8, 12, 24, 36) product series.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable