QBD10593

DBCO-dPEG ^®₁₂-MAL

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₅₂H₇₄N₄O₁₇
• Molecular Weight: 1027.16
• UNSPSC Code: 51171641
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reagent type: cross-linking reagent; reaction type: click chemistry
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)NCCC(N2C3=C(C#CC4=C(C2)C=CC=C4)C=CC=C3)=O

Description

General description

DBCO-dPEG^®₁₂-MAL is a versatile heterobifunctional cross-linking reagent used in strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. This approach is also known as copper-free click chemistry. The presence of maleimidopropyl (MAL) functional group in the reagent forms a thiol-ether linkage with sulfhydryl groups.

Features and Benefits

DBCO-dPEG ^®₁₂-MAL can be used to conjugate two different proteins or an antibody with a payload by using copper-free "click" chemistry with the DBCO and reaction of the maleimide with a free thiol.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable