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Key Documents

923311

Sigma-Aldrich

4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid

Synonym(s):

Rigid linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C17H22N2O5
Molecular Weight:
334.37
UNSPSC Code:
12352106
NACRES:
NA.22

form

powder

Quality Level

reaction suitability

reagent type: linker

functional group

Boc
carboxylic acid

storage temp.

2-8°C

SMILES string

OC(C1=CC(OC2CC3(C2)CN(C(OC(C)(C)C)=O)C3)=CC=N1)=O

Application

4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
923338
923370
923419
923346
923427

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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