901567

Propargyl-PEG₁-acid

≥95%

• Empirical Formula (Hill Notation): C₆H₈O₃
• CAS Number: 55683-37-9
• Molecular Weight: 128.13
• MDL number: MFCD10689189
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• assay: ≥95%
• form: liquid
• reaction suitability: reagent type: linker
• functional group: alkyne; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(CCOCC#C)=O
• InChI: 1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)
• InChI key: GMFDYXLFHSFUHE-UHFFFAOYSA-N

Description

Application

Propargyl-PEG₁-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₁-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3