803421
LC-SDA (NHS-LC-Diazirine) (succinimidyl 6-(4,4′-azipentanamido)hexanoate)
About This Item
Recommended Products
assay
≥90%
Quality Level
form
powder
mol wt
338.36
reaction suitability
reagent type: cross-linking reagent
storage condition
desiccated
solubility
DMSO or DMF: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
CC1(N=N1)CCC(NCCCCCC(ON2C(CCC2=O)=O)=O)=O
InChI
1S/C15H22N4O5/c1-15(17-18-15)9-8-11(20)16-10-4-2-3-5-14(23)24-19-12(21)6-7-13(19)22/h2-10H2,1H3,(H,16,20)
InChI key
DYNYVLFTFJHMCW-UHFFFAOYSA-N
General description
Features and Benefits
- Membrane-permeable—suitable for in vivo intracellular protein crosslinking
- Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
- Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
- Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
- Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution
Related product
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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