636401

Phthalylglycyl chloride

96%

• Synonym(s): 1,3-Dioxo-2-isoindolineacetyl chloride, NSC 401729, Phthalylglycine acid chloride
• Empirical Formula (Hill Notation): C₁₀H₆ClNO₃
• CAS Number: 6780-38-7
• Molecular Weight: 223.61
• EC Number: 229-840-8
• MDL number: MFCD00192872
• UNSPSC Code: 12352100
• PubChem Substance ID: 24882779
• NACRES: NA.22

Properties

• assay: 96%
• form: solid
• SMILES string: ClC(=O)CN1C(=O)c2ccccc2C1=O
• InChI: 1S/C10H6ClNO3/c11-8(13)5-12-9(14)6-3-1-2-4-7(6)10(12)15/h1-4H,5H2
• InChI key: RHZBRCQIKQUQHQ-UHFFFAOYSA-N

Description

General description

Phthalylglycyl chloride can be synthesized via reaction of phthalyl-glycine with thionyl chloride.

Application

Phthalylglycyl chloride can be used in the synthesis of N-Phthalimidoacetyl-β-phenylethylamnine.

Reactant involved in:

• Synthesis of selenium-containing amino acid analogs with bactericidal and antifungal activity
• Photoinduced single electron transfer cyclization for preparation of cyclic peptides
• Arndt-Eistert synthesis
• Mitsunobu and arbuzov-type multicomponent pathway
• Remote C-H bond functionalization
• Amido-alkylation for synthesis of benzofuran derivatives

Safety Information

• pictograms: GHS06,GHS05
• signalword: Danger
• hcodes: H301,H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges