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Key Documents

437379

Sigma-Aldrich

2-Ethylhexyl salicylate

99%

Synonym(s):

Octisalate, Octyl salicylate

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About This Item

Linear Formula:
(HO)C6H4CO2CH2CH(C2H5)(CH2)3CH3
CAS Number:
Molecular Weight:
250.33
Beilstein/REAXYS Number:
2730664
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Quality Level

assay

99%

form

liquid

refractive index

n20/D 1.502 (lit.)

bp

189-190 °C/21 mmHg (lit.)

density

1.014 g/mL at 25 °C (lit.)

SMILES string

CCCCC(CC)COC(=O)c1ccccc1O

InChI

1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

InChI key

FMRHJJZUHUTGKE-UHFFFAOYSA-N

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General description

2-Ethylhexyl salicylate(EHS) is an organic ultraviolet(UV) absorber that can be used as a photostable ingredient in cosmetic formulations. It shows an absorption spectra in the range of 280-320 nm in the UV region.

Application

EHS is a salicylic ester which can be used as an UV filter in sunscreen based creams.

pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Chronic 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

323.6 °F - closed cup

flash_point_c

162 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Optical and electron paramagnetic resonance studies of the excited triplet states of UV-B absorbers: 2-ethylhexyl salicylate and homomenthyl salicylate.
Sugiyama K, et al.
Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology, 14(9), 1651-1659 (2015)
A pendant peptide endows a sunscreen with water-resistance.
Ellison AJ and Raines RT
Organic & Biomolecular Chemistry, 16(39), 7139-7142 (2018)
M McVean et al.
Molecular carcinogenesis, 24(3), 169-176 (1999-04-16)
Topical application of alpha-tocopherol (alphaTH), the most prominent naturally occurring form of vitamin E, inhibits ultraviolet (UV) B-induced photocarcinogenesis and DNA photodamage in C3H mice in vivo. In this study, we compared alphaTH with other vitamin E compounds and with
R Jiang et al.
Journal of pharmaceutical sciences, 86(7), 791-796 (1997-07-01)
This study provides an investigation of the availability of octyl salicylate (OS), a common sunscreen agent, from liquid paraffin and the effect of OS on skin permeability. A model membrane system to isolate the vehicle effect from membrane permeability has
M McVean et al.
Carcinogenesis, 18(8), 1617-1622 (1997-08-01)
Ultraviolet B (UVB, 290-320 nm) exposure results in a variety of cellular insults including induction of cyclobutane pyrimidine dimers in DNA. Accumulation of these lesions can lead to mutations in critical genes and contribute to the development of nonmelanoma skin

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