39410

4-(Dimethylamino)pyridine, polymer-bound

extent of labeling: ~3.0 mmol/g "DMAP" loading, matrix crosslinked with 2% DVB

• Synonym(s): 4-(Dimethylamino)pyridine on Polystyrene, DMAP on PS, polymer bound DMAP
• Empirical Formula (Hill Notation): C₈H₈
• CAS Number: 82942-26-5
• Molecular Weight: 104.15
• MDL number: MFCD04041220
• UNSPSC Code: 12352128
• PubChem Substance ID: 57649897
• NACRES: NA.22

Properties

• reaction suitability: reaction type: solution phase peptide synthesis
• extent of labeling: ~3.0 mmol/g "DMAP" loading
• matrix: crosslinked with 2% DVB
• anion traces: chloride (Cl^-): ≤5000 mg/kg

Description

General description

Polymer-bound 4-(dimethylamino)pyridine is used for improved derivatization of chiral and achiral aliphatic amines, amino alcohols and amino acids.

Application

Polymer-bound 4-(dimethylamino)pyridine is used as a supported base in the Michael addition and nitrous acid elimination process step involved in the synthesis of thiophene-2-carboxylates using β-nitroacrylates as starting materials, under a general and efficient continuous flow-based protocol. It also serves as a supported catalyst in the preparation of ω-nitro esters starting from cyclic 2-nitro ketones under solid heterogeneous catalysis.(5)

Other Notes

Polymer supported, recyclable acylation catalyst

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)