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357650

Sigma-Aldrich

4-Chlorodiphenyl ether

99%

Synonym(s):

4-Chlorophenyl phenyl ether

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About This Item

Linear Formula:
ClC6H4OC6H5
CAS Number:
7005-72-3
Molecular Weight:
204.65
EC Number:
230-281-7
MDL number:
MFCD00055431
UNSPSC Code:
12352100
PubChem Substance ID:
24861931
NACRES:
NA.22

Quality Level

100

assay

99%

form

liquid

refractive index

n20/D 1.587 (lit.)

bp

161-162 °C/19 mmHg (lit.)

density

1.193 g/mL at 25 °C (lit.)

SMILES string

Clc1ccc(Oc2ccccc2)cc1

InChI

1S/C12H9ClO/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9H

InChI key

PGPNJCAMHOJTEF-UHFFFAOYSA-N

General description

4-Chlorodiphenyl ether is halogenated diphenyl ether. It is an estrogenic contaminant and its effect on the growth of endometrial implants has been investigated. Dehalogenations of 4-chlorodiphenyl ether at 375°C over CaO/Ca(OH)2 has been reported.

Application

4-Chlorodiphenyl ether can be used in the preparation of 4′-chloro-2,2′,3,3′,4,5,5′,6,6′-nonabromodiphenyl ether (Cl-BDE-208), an internal standard used in the analysis of highly brominated diphenyl ethers.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H319,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113.0 °C - closed cup

Certificates of Analysis (COA)

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Yang C and Pittman JR CU
Hazardous Waste and Hazardous Materials, 13(4), 445-464 (1996)
Y C Chui et al.
Drug metabolism and disposition: the biological fate of chemicals, 15(1), 44-50 (1987-01-01)
The metabolic disposition of 14C-labeled 4-chlorodiphenyl ether ([14C]4-CDE) was examined in rats following iv administration of a single dose (850 nmol/kg). [14C]4-CDE decayed rapidly from the blood since no unchanged [14C]4-CDE was detected in the blood beyond 2 hr after
W G Foster et al.
Canadian journal of physiology and pharmacology, 75(10-11), 1188-1196 (1998-02-12)
Surgically induced endometriosis in the mouse has been described as a model to investigate the effect of environmental pollutants on the growth of endometriotic implants. The objectives of this study were to evaluate a modified surgical procedure to induce endometriosis
J Z Yang et al.
Reproductive toxicology (Elmsford, N.Y.), 11(1), 69-75 (1997-01-01)
The objectives of this study were to evaluate the effects of repeated injection of 4-chlorodiphenyl ether (4-CDE) on the survival and growth of endometriotic implants. Endometriosis was surgically induced in adult female B6C3F1 mice (n = 25) after ovariectomy. Seven
Anna Christiansson et al.
Chemosphere, 63(4), 562-569 (2005-11-22)
Polybrominated diphenyl ethers (PBDEs) have been used extensively as brominated flame retardants (BFRs) in textiles, upholstery and electronics. They are ubiquitous contaminants in wildlife and humans. A low concentration of nonabrominated diphenyl ethers (nonaBDEs) is present in commercial DecaBDE and

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