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347574

Sigma-Aldrich

trans-4-Cotininecarboxylic acid

97%

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About This Item

Empirical Formula (Hill Notation):
C11H12N2O3
CAS Number:
33224-01-0
Molecular Weight:
220.22
MDL number:
MFCD00075394
UNSPSC Code:
12352100
PubChem Substance ID:
24861513
NACRES:
NA.22

assay

97%

mp

194-195 °C (lit.)

SMILES string

CN1[C@@H]([C@H](CC1=O)C(O)=O)c2cccnc2

InChI

1S/C11H12N2O3/c1-13-9(14)5-8(11(15)16)10(13)7-3-2-4-12-6-7/h2-4,6,8,10H,5H2,1H3,(H,15,16)/t8-,10+/m0/s1

InChI key

DEYLVDCFTICBTB-WCBMZHEXSA-N

General description

Carboxyl group of trans-4-cotininecarboxylic acid (carboxycotinine) can be used for chemical crosslinking.

Application

trans-4-Cotininecarboxylic acid was used in the preparation of cotinine-conjugated horseradish peroxidase during immunoblot analysis. Anion of trans-4-cotininecarboxylic acid has been employed as pyridyl-carboxylate ligand in the preparation of polymeric copper(II) complex.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Hyori Kim et al.
Experimental & molecular medicine, 45, e43-e43 (2013-09-28)
We present a bispecific antibody that recognizes an antigen and a hapten and can be applied to various biological assays, including immunoblotting and immunoprecipitation. In immunoblot analysis of serum, an anti-C5 × anti-cotinine bispecific tandem single-chain variable fragment (scFv)-Fc fusion
Soomin Yoon et al.
Journal of cancer research and clinical oncology, 140(2), 227-233 (2013-12-03)
Cotinine has optimal characteristics as a hapten for pre-targeted radioimmunotherapy (PRIT). This study was performed to evaluate the applicability of cotinine/anti-cotinine antibody to PRIT. We developed and prepared a tandem, single-chain, variable fragment Fc fusion protein [tandem single-chain variable fragment
The use of trans-4-cotininecarboxylate to construct a polymeric copper (II) azido complex: Hydro (solvo) thermal synthesis, structure and magnetic properties.
Luo F, et al.
Inorgorganica Chimica Acta, 363(14), 4117-4122 (2010)

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