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335673

Sigma-Aldrich

1-Dodecyl-2-pyrrolidinone

99%

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About This Item

Empirical Formula (Hill Notation):
C16H31NO
CAS Number:
2687-96-9
Molecular Weight:
253.42
EC Number:
403-730-1
MDL number:
MFCD00075066
UNSPSC Code:
12352100
PubChem Substance ID:
24860339
NACRES:
NA.22

assay

99%

form

viscous liquid

refractive index

n20/D 1.466 (lit.)

bp

202-205 °C/11 mmHg (lit.)

density

0.89 g/mL at 25 °C (lit.)

SMILES string

CCCCCCCCCCCCN1CCCC1=O

InChI

1S/C16H31NO/c1-2-3-4-5-6-7-8-9-10-11-14-17-15-12-13-16(17)18/h2-15H2,1H3

InChI key

NJPQAIBZIHNJDO-UHFFFAOYSA-N

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General description

1-Dodecyl-2-pyrrolidinone is an N-alkyl lactam and its reduction with LiH3BNMe2 to the corresponding amine has been reported. It is a potential melatonin-specific chemical penetration enhancer.

Application

1-Dodecyl-2-pyrrolidinone was used in the preparation of few-layered flakes of molybdenum disulfide (MoS2) via liquid phase exfoliation of bulk MoS2 powder.

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM0898
MKBZ4498V
MKBJ2361V
MKBH4471V
MKBF6943V

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S Sato et al.
Chemical & pharmaceutical bulletin, 46(5), 831-836 (1998-06-11)
The enhancing effects of N-dodecyl-2-pyrrolidone (NDP) on the percutaneous absorption of doxifluridine (DOX), 5-fluorouracil (5-FU), tegafur (TEG) and carmofur (CAR) were examined using an in vitro penetration technique and rat skin. Phosphate buffered isotonic saline (PBS), propylene glycol (PG) and
Andrew Winchester et al.
ACS applied materials & interfaces, 6(3), 2125-2130 (2014-01-22)
We report on the electrochemical charge storage behavior of few-layered flakes of molybdenum disulfide (MoS2) obtained by liquid phase exfoliation of bulk MoS2 powder in 1-dodecyl-2-pyrrolidinone. The specific capacitances of the exfoliated flakes obtained using a 6 M KOH aqueous
Srinivas S Godavarthy et al.
Journal of pharmaceutical sciences, 98(11), 4085-4099 (2009-08-22)
One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical
Vijay Krishna Rachakonda et al.
Pharmaceutical research, 25(11), 2697-2704 (2008-08-07)
A novel technique is presented for identifying potential chemical penetration enhancers (CPEs) based on changes in the electrical resistance of skin. Specifically, a multi-well resistance chamber was designed and constructed to facilitate more rapid determination of the effect of CPEs
H Sasaki et al.
The Journal of pharmacy and pharmacology, 42(3), 196-199 (1990-03-01)
The enhancing effect of combining 1-methyl-2-pyrrolidone (MP) and 1-lauryl-2-pyrrolidone (LP) as the vehicles for transdermal penetration of phenolsulphonphthalein (phenol red) has been investigated by using an in-vitro technique with excised rat skin. LP had a higher enhancing effect on the
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