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Sigma-Aldrich

Methyl 4-methoxyacetoacetate

97%

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About This Item

Linear Formula:
CH3OCH2COCH2COOCH3
CAS Number:
41051-15-4
Molecular Weight:
146.14
Beilstein/REAXYS Number:
1761215
EC Number:
255-188-9
MDL number:
MFCD00010183
UNSPSC Code:
12352100
PubChem Substance ID:
24856977
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.431 (lit.)

bp

89 °C/8.5 mmHg (lit.)

density

1.129 g/mL at 25 °C (lit.)

SMILES string

COCC(=O)CC(=O)OC

InChI

1S/C6H10O4/c1-9-4-5(7)3-6(8)10-2/h3-4H2,1-2H3

InChI key

QGBPKJFJAVDUNC-UHFFFAOYSA-N

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Application

Methyl 4-methoxyacetoacetate has been used in generation of a small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and (thio)ureas.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Doris Dallinger et al.
Nature protocols, 2(7), 1713-1721 (2007-07-21)
Here we report the generation of a small focused library of 12 diversely functionalized dihydropyrimidine (DHPM) derivatives via one-pot three-component Biginelli cyclocondensation of beta-ketoesters, aldehydes and (thio)ureas. By applying controlled microwave heating under sealed vessel conditions using a fully automated

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