RPE65
retinal pigment epithelium-specific protein 65kDa
Synonyms:
LCA2, RP20, mRPE65, rd12, sRPE65
Species:
Human RPE65 (6121), Mouse Rpe65 (19892), Rat Rpe65 (89826), cow RPE65 (282043), sheep RPE65 (101116520), domestic guinea pig Rpe65 (100721944), naked mole-rat Rpe65 (101716560), Domestic Rabbit RPE65 (100352270), chicken RPE65 (395700), domestic cat RPE65 (101090034)
UniProtKB ID:
Gene ID:
- Human(6121) Summary: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]
- Mouse(19892) retinal pigment epithelium 65
- Rat(89826) retinal pigment epithelium 65
- cow(282043) retinal pigment epithelium-specific protein 65kDa
- sheep(101116520) retinal pigment epithelium-specific protein 65kDa
- domestic guinea pig(100721944) retinal pigment epithelium-specific protein 65kDa
- naked mole-rat(101716560) retinal pigment epithelium-specific protein 65kDa
- Domestic Rabbit(100352270) retinal pigment epithelium-specific protein 65kDa
- chicken(395700) retinal pigment epithelium-specific protein 65kDa
- domestic cat(101090034) retinal pigment epithelium-specific protein 65kDa
- dog(403803) retinal pigment epithelium-specific protein 65kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RPE65 Antibody, clone 2F8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rabbit
Application
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-RPE65 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
western blot
western blot
Anti-RPA70 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Anti-RPE65 Antibody, clone KPSA1, ,
Species Reactivity
bovine, human, mouse
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-RPE65 Antibody, clone 401.8B11.3D9 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
xenopus, bovine, canine, human, monkey, mouse, porcine, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot