Przejdź do zawartości
Merck
  • Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi.

Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi.

Journal of inorganic biochemistry (2017-09-15)
Marzena Fandzloch, José Manuel Méndez Arriaga, Manuel Sánchez-Moreno, Andrzej Wojtczak, Julia Jezierska, Jerzy Sitkowski, Joanna Wiśniewska, Juan Manuel Salas, Iwona Łakomska
ABSTRAKT

Tropical diseases currently constitute a major health problem and thus a challenge in the field of drug discovery. The current treatments show serious disadvantages due to cost, toxicity, long therapy duration and resistance, and the use of metal complexes as chemotherapeutic agents against these ailments appears to be a very attractive alternative. Herein, we describe three newly synthesized ruthenium complexes with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cis,fac-[RuCl

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
Ruthenium(III) chloride, Ru content 45-55%
Sigma-Aldrich
3-Methyl-2,4-pentanedione, mixture of tautomers, technical grade, 85%