APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.

APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.

eLife (2017-01-06)

Ming Chen, Jinzhao Wang, Jinxiang Jiang, Xingzhi Zheng, Nicholas J Justice, Kun Wang, Xiangqian Ran, Yi Li, Qingwei Huo, Jiajia Zhang, Hongmei Li, Nannan Lu, Ying Wang, Hui Zheng, Cheng Long, Li Yang

PMID28054918

ABSTRAKT

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in

MATERIAŁY

Numer produktu

Marka

Opis produktu

07-432

Sigma-Aldrich

Przeciwciało przeciw kotransporterowi K+/Cl- (KCC2), Upstate^®, from rabbit

T6557

Sigma-Aldrich

Anti-γ-Tubulin antibody, Mouse monoclonal, clone GTU-88, ascites fluid

16-452

Sigma-Aldrich

11971 Platyna, przeciwciało przeciw fosfotyrozynie, koniugat biotyny, clone 4G10®, Upstate^®, from mouse

06-868

Sigma-Aldrich

Przeciwciało przeciwko receptorowi GABAA α1, Upstate^®, from rabbit